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3-hydroxyphenazepam 30 Pills

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3-Hydroxyphenazepam (3OH-PBZ) is a psychoactive substance belonging to the benzodiazepine class. It is a minor metabolite of phenazepam, a widely used sedative drug. 3OH-PBZ exhibits similar pharmacological properties to its parent compound and is being studied for its therapeutic potential. This document aims to provide an overview of the chemical structure, mechanism of action, and current research surrounding 3OH-PBZ.

Chemical Structure

3-Hydroxyphenazepam has a chemical structure similar to phenazepam, differing primarily in the presence or lack of a hydroxyl group on the 3-position of the B-ring of the benzodiazepine nucleus. This structural modification affects its pharmacological properties and pharmacokinetics.

Mechanism of Action

Benzodiazepines bind to specific receptors in the brain, primarily the GABA-A receptor. When activated, these receptors modulate the activity of GABA, a neurotransmitter associated with relaxation and reduced anxiety. 3OH-PBZ acts as a partial agonist at the GABA-A receptor, enhancing GABA’s inhibitory effects and contributing to its sedative effects.


3OH-PBZ undergoes extensive metabolism in the body, primarily in the liver. Some of the metabolites formed during this process may be active, contributing to its pharmacological effects. The pharmacokinetics of 3OH-PBZ are not fully understood, but it is presumed to be cleared from the body through the kidneys.

Therapeutic Applications

3OH-PBZ has shown promise as a potential therapeutic agent in various conditions. It has been investigated for its potential as an anticonvulsant, antidepressant, and neuroprotective agent. However, further research is still needed to establish its clinical efficacy and safety profiles.


3-Hydroxyphenazepam, a minor metabolite of phenazepam, exhibits similar pharmacological properties to its parent compound. It is being studied for its potential therapeutic applications, particularly in epilepsy, depression, and neurodegenerative disorders. However, further research is needed to understand the full therapeutic potential and safety of 3OH-PBZ.


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