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5-Aminoisotonitazene (5-IT) is a synthetic compound that belongs to the group of dissociative anesthetics. It was first discovered in the 1960s and has gained attention due to its potential therapeutic applications and medicinal properties. In this guide, we will explore the chemistry, structure, synthesis, and potential uses of 5-IT.


5-IT is a colorless liquid with a slightly sweet odor. It has a low molecular weight of 145.16 g/mol and belongs to the phenethylamine class. The compound has a benzene ring with an isopropyl side chain attached to one of its carbon atoms. The side chain contains a nitrogen atom, which plays a crucial role in its distinct properties.


The chemical structure of 5-IT can be represented as:

Structure of 5-Aminoisotonitazene


The synthesis of 5-IT involves several steps. First, 2-chloro-5-(4-nitrophenyl)-2,3-dihydro-1H-inden-1-one is reacted with ethyl chloroformate. The resulting intermediate is then reduced using sodium borohydride, resulting in the formation of 5-IT. The synthesis of 5-IT can vary based on the specific reaction conditions and reagents employed.

Uses of 5-Aminoisotonitazene

5-IT has been investigated for its potential therapeutic applications. It has been studied for its potential as anesthetic, antidepressant, and analgesic agent. However, further research is needed to determine its safety and efficacy in humans.

Additionally, 5-IT has also been studied for its psychoactive effects. It exhibits similar hallucinogenic properties to drugs like ketamine and LSD, suggesting its potential use as a recreational drug. However, its legal status varies across different jurisdictions, and its recreational use is not recommended.


5-Aminoisotonitazene is a synthetic compound belonging to the dissociative anesthetic class. It exhibits unique structural and pharmacological properties, making it a subject of ongoing research. While 5-IT has shown promise for therapeutic applications, further research is needed to determine its safety and efficacy. Its potential use as a recreational drug also raises concerns regarding its legality and potential harm.

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10 Gram, 25 Grams, 50 Grams, 100 Grams, 250 Grams, 500 Grams, 1000 Gram


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