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3-Methylfentanyl is a powerful synthetic opioid analgesic that belongs to the class of drugs known as fentanyl analogs. It is an analog of fentanyl, a highly potent synthetic opioid that is commonly used for pain management in medical settings. 3-Methylfentanyl was developed to help alleviate the misuse and abuse of fentanyl, as it offers similar analgesic effects but with a higher binding affinity to the μ-opioid receptor.

Structure and Properties

3-Methylfentanyl has a chemical structure similar to that of fentanyl, with the same functional groups present. It has a molecular weight of 312.77 g/mol and is characterized by a cyclopropyl ring attached to the piperidine ring of fentanyl. This structural modification enhances the lipophilicity and potency of the drug, making it more potent and addictive.

Unlike fentanyl, 3-Methylfentanyl has an enhanced binding affinity to the μ-opioid receptor, resulting in greater analgesic effects. It also exhibits a higher affinity for the σ-opioid receptor, which may contribute to its hallucinogenic effects. The binding affinity of 3-Methylfentanyl to the μ-opioid receptor is about 1.5 times that of fentanyl, making it a potent opioid analgesic.


3-Methylfentanyl acts primarily on the μ-opioid receptors, which are widely distributed throughout the body, including the brain, spinal cord, and digestive tract. By binding to these receptors, 3-Methylfentanyl triggers a cascade of events that ultimately lead to pain relief and feelings of euphoria.

One of the primary effects of 3-Methylfentanyl is analgesia, or pain relief. It binds to the μ-opioid receptors and inhibits the release of pain neurotransmitters, such as acetylcholine and norepinephrine. This inhibition reduces the perception of pain and the development of tolerance to the drug.

In addition to analgesia, 3-Methylfentanyl also produces other effects, including sedation, respiratory depression, and constipation. The sedation effect can lead to drowsiness, dizziness, and reduced motor coordination, while the respiratory depression can result in shallow breathing and reduced oxygen levels in the blood. The constipation effect is caused by the activation of μ-opioid receptors in the digestive tract, leading to reduced motility and constipation.

Uses and Abuse

3-Methylfentanyl is primarily used as a pain medication in medical settings, such as hospitals or clinics. It is administered intravenously or subcutaneously to provide immediate relief from severe pain. However, due to its high potency and potential for abuse, 3-Methylfentanyl is strictly controlled and only available by prescription.

Unfortunately, like other fentanyl analogs, 3-Methylfentanyl has also gained popularity among recreational drug users. Street names for 3-Methylfentanyl include “M-3,” “M3F,” and “MFF.” It is typically sold as a white or off-white powder and is snorted, injected, or ingested through various routes of administration. The abuse potential of 3-Methylfentanyl is higher than that of fentanyl, making it more dangerous and addictive.

Legality and Safety Concerns

3-Methylfentanyl is a Schedule I controlled substance in the United States, meaning it has a high potential for abuse and no accepted medical use. It is classified as an illegal substance under the Controlled Substances Act and is subject to strict regulations.

The misuse of 3-Methylfentanyl carries significant risks, including overdose, respiratory depression, cardiac arrest, and death. The potency of the drug makes it particularly dangerous, as even a small amount can lead to life-threatening complications. It is crucial for individuals seeking medical attention for opioid misuse or addiction to receive appropriate treatment and support.


3-Methylfentanyl is a powerful synthetic opioid analgesic that was developed to address the misuse and abuse of fentanyl. It has a higher binding affinity to the μ-opioid receptor and enhanced lipophilicity, making it more potent and addictive. The misuse of 3-Methylfentanyl, like other fentanyl analogs, carries significant risks, including overdose and death. Proper regulation of this drug and awareness regarding its dangers are essential in preventing its misuse and addressing the opioid crisis.

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